Hsia, Da Tepper, Cg Pochampalli, Mr Hsia, Ey Chie Izumiya Huerta, Sb Wright, Me Chen, Hw Kung, Hj Yoshihiro Izumiya
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Published in
Proceedings of the National Academy of Sciences
Localized chromatin modifications of histone tails play an important role in regulating gene transcription, and aberration of these processes leads to carcinogenesis. Methylated histone lysine residues, a key player in chromatin remodeling, are demethylated by the JmjC class of enzymes. Here we show that JMJD5 (now renamed KDM8), a JmjC family memb...
Bhatt, Ap Wong, Jp Weinberg, Ms Host, Km Giffin, Lc Buijnink, J Van Dijk, E Yoshihiro Izumiya Kung, Hj Temple, Br
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Published in
Proceedings of the National Academy of Sciences
Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading frame 36 (ORF36) of Kaposi s sarcoma-associated herpe...
Levy, Am Gilad, O Xia, L Yoshihiro Izumiya Choi, J Tsalenko, A Yakhini, Z Witter, R Lee, L Cardona, Cj
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Published in
Proceedings of the National Academy of Sciences
Marek s disease virus (MDV) is a highly pathogenic and oncogenic herpesvirus of chickens. MDV encodes a basic leucine zipper (bZIP) protein, Meq (MDV EcoQ). The bZIP domain of Meq shares homology with Jun/Fos, whereas the transactivation/repressor domain is entirely different. Increasing evidence suggests that Meq is the oncoprotein of MDV. Direct ...
