KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.
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Published in Nature communications
Weak electric fields guide cell migration, known as galvanotaxis/electrotaxis. The sensor(s) cells use to detect the fields remain elusive. Here we perform a large-scale screen using an RNAi library targeting ion transporters in human cells. We identify 18 genes that show either defective or increased galvanotaxis after knockdown. Knockdown of the ...
