Kaposi’s sarcoma-associated Herpesvirus K-bZIP represses gene transcription via SUMO modification
Published in Journal of Virology
Histone demethylase JMJD2A regulates Kaposi s sarcoma-associated herpesvirus replication and is targeted by a viral tran...
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Published in Journal of Virology
The switch between the latency and lytic cycles of Kaposi s sarcoma-associated herpesvirus (KSHV) is accompanied by specific alterations of histone codes. Recently, comprehensive analysis of histone modifications of KSHV showed the deposition of H3K27me3 across the KSHV genome with two specific regions occupied by the heterochromatin marker H3K9me3...
Kaposi s sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent tr...
Published in Journal of Virology
Kaposi s sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus that has been implicated in the pathogenesis of Kaposi s sarcoma and B-cell neoplasms. The genomic organization of KSHV is similar to that of Epstein-Barr virus (EBV). EBV encodes two transcriptional factors, Rta and Zta, which functionally interact to transactivate EBV gene...
Kaposi s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by associ...
Published in Journal of Virology
Kaposi s sarcoma-associated herpesvirus (KSHV) latent genomes are tethered to host histones to form a minichromosome also known as an "episome." Histones, which are core components of chromatin, are heavily modified by various histone-targeting enzymes. Posttranslational modifications of histones significantly influence accessibility of transcripti...
A lytic viral long noncoding RNA modulates the function of a latent protein.
Published in Journal of Virology
Latent Kaposi s sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociati...
Kaposi s sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP
Published in Journal of Virology
NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta ...
Published in Journal of virology
Successful viral replication is dependent on a conducive cellular environment; thus, viruses must be sensitive to the state of their host cells. We examined the idea that an interplay between viral and cellular regulatory factors determines the switch from Kaposi's sarcoma-associated herpesvirus (KSHV) latency to lytic replication. The immediate-ea...
Cell cycle regulation by Kaposi s sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and inducti...
Published in Journal of Virology
In order to cope with hostile host environments, many viruses have developed strategies to perturb the cellular machinery to suit their replication needs. Some herpesvirus genes protect cells from undergoing apoptosis to prolong the lives of infected cells, while others, such as Epstein-Barr virus Zta, slow down the G(1)/S transition phase to allow...
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek s dise...
Published in Journal of Virology
Marek s disease virus (MDV) is an acute transforming alphaherpesvirus that causes T-cell lymphomas in chickens. We previously reported the identification of a putative oncogene, meq, that is encoded only by the oncogenic serotype of MDV. The gene product, Meq, is a latent protein that is consistently expressed in MDV-transformed lymphoblastoid cell...
Homodimerization of Marek s Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chi...
Published in Journal of Virology
