Izumiya Lab - UC Davis
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News 27 Publications 5 Members

KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.

Nakajima, Ken-Ichi Zhu, Kan Sun, Yao-Hui Hegyi, Bence Zeng, Qunli Murphy, Christopher J Small, J Victor Chen-Izu, Ye Izumiya, Yoshihiro Penninger, Josef M ...

Published in Nature communications

Weak electric fields guide cell migration, known as galvanotaxis/electrotaxis. The sensor(s) cells use to detect the fields remain elusive. Here we perform a large-scale screen using an RNAi library targeting ion transporters in human cells. We identify 18 genes that show either defective or increased galvanotaxis after knockdown. Knockdown of the ...

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruse...

Schreiber, Claire A Sakuma, Toshie Izumiya, Yoshihiro Holditch, Sara J Hickey, Raymond D Bressin, Robert K Basu, Upamanyu Koide, Kazunori Asokan, Aravind Ikeda, Yasuhiro ...

Published in PLoS pathogens

Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper viruses, host factors such as the proteasome and DNA damage response machinery have been shown to effectively inhibit AAV transduction by restricting processe...

Long non-coding RNA and epigenetic gene regulation of KSHV.

Campbell, Mel Kung, Hsing-Jien Izumiya, Yoshihiro

Published in Viruses

Kaposi's sarcoma-associated herpesvirus (KSHV/human herpesvirus 8) is a γ-herpesvirus linked to Kaposi's sarcoma (KS) and two lymphoproliferative disorders, primary effusion lymphoma (PEL or body-cavity B-lymphoma [BCBL]) and a subset of Multicentric Castleman's Disease. During lytic growth, pervasive viral transcription generating a variety of tra...

Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV.

Campbell, Mel Izumiya, Yoshihiro

Published in Frontiers in microbiology

KSHV latency can be envisioned as an outcome that is balanced between factors that promote viral gene expression and lytic replication against those that facilitate gene silencing and establish or maintain latency. A large body of work has focused on the activities of the key viral regulatory proteins involved in KSHV latent or lytic states. Moreov...

Kaposi s Sarcoma-associated Herpesvirus (KSHV) Encodes a SUMO E3 ligase That Is SIM-dependent and SUMO-2/3-specific

Chang, Pei-Ching Yoshihiro Izumiya Wu, Chun-Yi Fitzgerald, Latricia D Campbell, Mel Ellison, Thomas J Lam, Kit S Luciw, Paul A Kung, Hsing-Jien

Published in Journal of Biological Chemistry

NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta ...

Izumiya, Yoshihiro Izumiya, Chie Hsia, Datsun Ellison, Thomas J Luciw, Paul A Kung, Hsing-Jien

Published in Journal of virology

Successful viral replication is dependent on a conducive cellular environment; thus, viruses must be sensitive to the state of their host cells. We examined the idea that an interplay between viral and cellular regulatory factors determines the switch from Kaposi's sarcoma-associated herpesvirus (KSHV) latency to lytic replication. The immediate-ea...

Kruppel-Associated Box Domain-Associated Protein-1 as a Latency Regulator for Kaposi s Sarcoma-Associated Herpesvirus an...

Chang, Pei-Ching Fitzgerald, Latricia D Van Geelen, Albert Yoshihiro Izumiya Ellison, Thomas J Wang, Don-Hong Ann, David K Luciw, Paul A Kung, Hsing-Jien

Published in Cancer Research

Homodimerization of Marek s Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in Chi...

Suchodolski#, Paulette F Yoshihiro Izumiya Lupiani, Blanca Ajithdoss, Dharani K Gilad, Oren Lee, Lucy F Kung, Hsing-Jien Reddy, Sanjay M

Published in Journal of Virology

Regulation of Id1 Expression by Src: Implications for Targeting of the Bone Morphogenetic Protein Pathway in Cancer

Gautschi, Oliver Tepper, Clifford G Purnell, Phillip R Yoshihiro Izumiya Evans, Christopher P Green, Tim P Desprez, Pierre Y Lara, Primo N Gandara, David R Mack, Philip C ...

Published in Cancer Research

Kaposi s sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP

Yoshihiro Izumiya Chie Izumiya Vangeelen, Albert M Wang, Don-Hong Lam, Kit S Luciw, Paul A Kung, Hsing-Jien

Published in Journal of Virology

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